Ku80 (XRCC5) Mouse Monoclonal Antibody [Clone ID: 8H1-C3-G10]

CAT#: TA347072

Mouse Monoclonal Ku80 Antibody

Specifications

Product Data

• Clone Name: 8H1-C3-G10
• Applications: IF, IP, WB
• Recommended Dilution: WB: 1:1000, IF: 1:400, IP: 1:100
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: The immunogen for XRCC5 antibody: purified recombinant human Ku80 protein fragments expressed in E.coli
• Formulation: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 86 kDa
• Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 5
• Database Link:
  NP_066964
  Entrez Gene 574279 MonkeyEntrez Gene 7520 Human
  UniProt ID P13010
• Background: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. (provided by RefSeq, Jul 2008).
• Synonyms: KARP-1; KARP1; KU80; Ku86; KUB2; NFIV

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Non-homologous end-joining