HP1 alpha (CBX5) Rabbit Polyclonal Antibody

CAT#: TA347093

Rabbit Polyclonal HP1 alpha, beta and gamma Antibody

Product Images

WB was performed on nuclear extracts from HeLa cells (HeLa NE, 20 ug) using the antibody against HP1 alpha, beta and gamma diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A molecular weight marker (in kDa) is shown on the left. The location of the three HP1 isoforms is indicated on the right.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blotting (1:1,000)
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-HP1 alpha, beta and gamma antibody: human HP1 beta (Heterochromatin protein 1 homolog beta), using the full length recombinant GST tagged protein. The antibody also recognizes the alpha and gamma isoforms.
• Concentration: lot specific
• Purification: Whole antiserum from rabbit containing 0.05% azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: chromobox 5
• Database Link:
  NP_036249
  Entrez Gene 23468 Human
  UniProt ID P45973
• Background: HP1 alpha, beta and gamma (UniProtKB/Swiss-Prot entry P45973, P83916 and Q13185) are components of heterochromatin. They recognize and bind histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 alpha, beta and gamma also interact with lamin B receptor (LBR) and can contribute to the association of the heterochromatin with the inner nuclear membrane.
• Synonyms: HEL25; HP1; HP1A