KDM1A Rabbit Polyclonal Antibody

CAT#: TA347223

Rabbit Polyclonal LSD1 Antibody


USD 490.00

5 Days*

Size
    • 50 ug

Product Images

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Specifications

Product Data
Applications ELISA, IP, WB
Recommended Dilution ELISA (1:100); Western blotting (1:1,000); Immunoprecipitation (2 g/IP)
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-LSD1 antibody: human JMJD2a (Jumonji domain containing 2a), using a KLH-conjugated synthetic peptide containing a sequence from the central part of the protein.
Concentration lot specific
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name lysine demethylase 1A
Background LSD1 (lysine specific demethylase 1, UniProt/Swiss-Prot entry O60341) is a component of the histone demethylase complex which uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated 'Lys-4' of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. As a consequence, LSD1 is involved in different processes such as embryonic development, cell differentiation and proliferation, and stem and cancer cell biology.
Synonyms AOF2; BHC110; CPRF; KDM1; LSD1
Reference Data
Protein Families Druggable Genome, Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.