LEO1 Rabbit Polyclonal Antibody

CAT#: TA347237

Rabbit Polyclonal Leo1 Antibody

Product Images

WB using the antibody against hLeo1 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. A MW marker is shown on the left, the location of the protein of interest is shown on the right.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blotting (1:2,000)
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Leo1 antibody: human Leo1 (component of the human PAF1/RNA polymeraseII complex), using the full length recombinant protein.
• Concentration: lot specific
• Purification: Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: LEO1 homolog, Paf1/RNA polymerase II complex component
• Database Link:
  NP_620147
  Entrez Gene 123169 Human
  UniProt ID Q8WVC0
• Background: PAF is a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9, which was first purified from yeast. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. The human PAF (hPAF) complex shares four subunits with yPAF (hCtr9, hPaf1, hLeo1 and Cdc73), but contains an additional higher eukaryotic-specific subunit, hSki8. In addition to coordinating events during transcription (initiation, promoter clearance and elongation); PAF also coordinates events in RNA quality control.
• Synonyms: RDL