MECP2 Rabbit Polyclonal Antibody

CAT#: TA347244

Rabbit Polyclonal MeCP2 Antibody


USD 430.00

5 Days*

Size
    • 50 ug

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Specifications

Product Data
Applications WB
Recommended Dilution Western blotting (1:1,000)
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-MeCP2 antibody: human MeCP2 (Methyl-CpG-binding domain protein 2), using a recombinant protein.
Concentration lot specific
Purification Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name methyl-CpG binding protein 2
Background MeCP2 (UniProt/Swiss-Prot entry P51608) is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism.
Synonyms AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Reference Data
Protein Families Druggable Genome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.