RbAp48 (RBBP4) Mouse Monoclonal Antibody

CAT#: TA347273

Mouse Monoclonal RbAp 46/48 Antibody

Product Images

WB was performed using nuclear extracts from HeLa cells (HeLa NE, 20 ug) and the antibody against hRbAp46/48 diluted 1:1,000 in TBS-Tween containing 5% skimmed milk. The molecular weight marker (in kDa) is shown on the left), the position of the protein of interest is shown on the right.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blotting (1:1,000)
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: The immunogen for anti-RbAp 46/48 antibody: the full length human RbAp48 protein (Retinoblastoma-binding protein p48) fused to GST. The antibody recognizes both RbAp48 and RbAp46.
• Concentration: lot specific
• Purification: Protein G purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RB binding protein 4, chromatin remodeling factor
• Database Link:
  NP_005601
  Entrez Gene 5928 Human
• Background: RbAp48 (UniProtKB/Swiss-Prot entry Q09028) is a component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodelling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Therefore it may target chromatin assembly factors as well as chromatin remodeling factors and histone deacetylases to their histone substrates in a nucleosomal DNA dependent manner.
• Synonyms: lin-53; NURF55; RBAP48

Reference Data

• Protein Families: Druggable Genome, Transcription Factors