RUNX1 Rabbit Polyclonal Antibody

CAT#: TA347279

Rabbit Polyclonal AML1-ETO Antibody


USD 490.00

5 Days*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications ELISA, WB
Recommended Dilution ChIP/ChIP-seq (4ul/ChIP); ELISA (1:500); Western blotting (1:1,000)
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-AML1-ETO antibody: the AML1-ETO fusion protein using a KLH-conjugated synthetic peptide.
Concentration lot specific
Purification Whole antiserum from rabbit containing 0.05% azide.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name runt related transcription factor 1
Background This antibody specifically recognizes the AML1 (RUNX1) (UniProtKB/Swiss-Prot entry Q01196) - ETO (RUNX1T1) (UniProtKB/Swiss-Prot entry Q06455) fusion protein that arises due to a translocation between chromosome 8 and 22 (t(8;21)(q22;q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukaemia. It produces a chimerical gene made up of the 5'-region of AML1and the 3'-region of ETO. The chimerical protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Synonyms AML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways Acute myeloid leukemia, Chronic myeloid leukemia, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.