Mps1 (TTK) Rabbit Polyclonal Antibody

CAT#: TA347333

Rabbit Polyclonal Anti-TTK Antibody

Product Images

Western blot analysis on HuvEc cell lysate using TTK Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TTK Antibody: A synthesized peptide derived from human TTK
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 100 kDa
• Gene Name: TTK protein kinase
• Database Link:
  NP_003309
  Entrez Gene 22137 MouseEntrez Gene 7272 Human
  UniProt ID P33981
• Background: TTK a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore.
• Synonyms: CT96; ESK; MPH1; MPS1; MPS1L1; PYT
• Note: TTK antibody detects endogenous levels of total TTK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cell cycle, Oocyte meiosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway