RAD17 Rabbit Polyclonal Antibody

CAT#: TA347338

Rabbit Polyclonal Anti-RAD17 Antibody

Product Images

Western blot analysis on HeLa cell lysate using RAD17 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-RAD17 Antibody: A synthesized peptide derived from human RAD17
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 77 kDa
• Gene Name: RAD17 checkpoint clamp loader component
• Database Link:
  NP_579922
  Entrez Gene 19356 MouseEntrez Gene 310034 RatEntrez Gene 5884 Human
  UniProt ID O75943
• Background: Rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported.
• Synonyms: CCYC; HRAD17; R24L; RAD17SP; RAD24
• Note: RAD17 antibody detects endogenous levels of total RAD17

Reference Data

• Protein Families: Druggable Genome