E2F6 Rabbit Polyclonal Antibody

CAT#: TA347374

Rabbit Polyclonal Anti-E2F6 Antibody

Product Images

Western blot analysis on HepG2 cell lysate using E2F6 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-E2F6 Antibody: A synthesized peptide derived from human E2F6
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 31 kDa
• Gene Name: E2F transcription factor 6
• Database Link:
  NP_937987
  Entrez Gene 50496 MouseEntrez Gene 313978 RatEntrez Gene 1876 Human
  UniProt ID O75461
• Background: E2F6 Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity.
• Synonyms: E2F-6
• Note: E2F6 antibody detects endogenous levels of total E2F6

Reference Data

• Protein Families: Transcription Factors