COPS3 Rabbit Polyclonal Antibody

CAT#: TA347408

Rabbit Polyclonal Anti-COPS3 Antibody

Product Images

Western blot analysis on LOVO cell lysate using COPS3 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-COPS3 Antibody: A synthesized peptide derived from human COPS3
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 47 kDa
• Gene Name: COP9 signalosome subunit 3
• Database Link:
  NP_003644
  Entrez Gene 26572 MouseEntrez Gene 287367 RatEntrez Gene 8533 Human
  UniProt ID Q9UNS2
• Background: COPS3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.
• Synonyms: CSN3; SGN3
• Note: COPS3 antibody detects endogenous levels of total COPS3

Reference Data

• Protein Families: Stem cell - Pluripotency