Parkin (PARK2) Rabbit Polyclonal Antibody

CAT#: TA347453

Rabbit Polyclonal Anti-Parkin Antibody

Product Images

Western blot analysis on HeLa cell lysate using Parkin Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Parkin Antibody: A synthesized peptide derived from human Parkin
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: parkin RBR E3 ubiquitin protein ligase
• Database Link:
  NP_054642
  Entrez Gene 50873 MouseEntrez Gene 56816 RatEntrez Gene 5071 Human
  UniProt ID O60260
• Background: PARK2 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2.
• Synonyms: AR-JP; LPRS2; PDJ; PRKN
• Note: Parkin antibody detects endogenous levels of total Parkin

Reference Data

• Protein Pathways: Parkinson's disease, Ubiquitin mediated proteolysis