PTCH1 Rabbit Polyclonal Antibody
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Other products for "PTCH1"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 1:500-1:3000 |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | The immunogen for anti-Patched Antibody: A synthesized peptide derived from human Patched |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt |
Concentration | lot specific |
Purification | Affinity-chromatography |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 160 kDa |
Gene Name | patched 1 |
Database Link | |
Background | PTCH1 a multi-pass membrane protein member of the patched family that acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Interacts with SNX17. Expressed in tumor cells but not in normal skin. |
Synonyms | BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11 |
Note | Patched antibody detects endogenous levels of total Patched |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer |
Documents
Product Manuals |
FAQs |
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