SIRP alpha (SIRPA) Rabbit Polyclonal Antibody

CAT#: TA347471

Rabbit Polyclonal Anti-SHPS1 Antibody

Product Images

Western blot analysis on HepG2 cell lysate using SHPS1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-SHPS1 Antibody: A synthesized peptide derived from human SHPS1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 55 kDa
• Gene Name: signal regulatory protein alpha
• Database Link:
  NP_542970
  Entrez Gene 19261 MouseEntrez Gene 25528 RatEntrez Gene 140885 Human
  UniProt ID P78324
• Background: SHPS1 Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
• Synonyms: BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
• Note: SHPS1 antibody detects endogenous levels of total SHPS1

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane