PIAS3 Rabbit Polyclonal Antibody

CAT#: TA347491

Rabbit Polyclonal Anti-PIAS3 Antibody

Product Images

Western blot analysis on 293 cell lysate using PIAS3 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-PIAS3 Antibody: A synthesized peptide derived from human PIAS3
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 68 kDa
• Gene Name: protein inhibitor of activated STAT 3
• Database Link:
  NP_006090
  Entrez Gene 83614 RatEntrez Gene 229615 MouseEntrez Gene 10401 Human
  UniProt ID Q9Y6X2
• Background: PIAS3 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Belongs to the PIAS family.
• Synonyms: ZMIZ5
• Note: PIAS3 antibody detects endogenous levels of total PIAS3

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis