XRCC4 Rabbit Polyclonal Antibody

CAT#: TA347510

Rabbit Polyclonal Anti-XRCC4 Antibody

Product Images

Western blot analysis on COLO205 cell lysate using XRCC4 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-XRCC4 Antibody: A synthesized peptide derived from human XRCC4
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 40 kDa
• Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 4
• Database Link:
  NP_072044
  Entrez Gene 7518 Human
  UniProt ID Q13426
• Background: XRCC4 Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Belongs to the XRCC4 family.
• Synonyms: SSMED
• Note: XRCC4 antibody detects endogenous levels of total XRCC4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Non-homologous end-joining