MAP4K4 Rabbit Polyclonal Antibody

CAT#: TA347637

Rabbit Polyclonal Anti-MEKKK 4 Antibody

Product Images

Western blot analysis on HuvEc cell lysate using MEKKK 4 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-MEKKK 4 Antibody: A synthesized peptide derived from human MEKKK 4
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 142 kDa
• Gene Name: mitogen-activated protein kinase kinase kinase kinase 4
• Database Link:
  NP_663719
  Entrez Gene 26921 MouseEntrez Gene 9448 Human
  UniProt ID O95819
• Background: a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.
• Synonyms: FLH21957; HEL-S-31; HGK; MEKKK4; NIK
• Note: MEKKK 4 Antibody detects endogenous levels of MEKKK 4

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway