BCAR3 Rabbit Polyclonal Antibody

CAT#: TA347659

Rabbit Polyclonal Anti-BCAR3 Antibody

Product Images

Western blot analysis on HeLa cell lysate using BCAR3 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-BCAR3 Antibody: A synthesized peptide derived from human BCAR3
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 92 kDa
• Gene Name: breast cancer anti-estrogen resistance 3
• Database Link:
  NP_003558
  Entrez Gene 8412 Human
  UniProt ID O75815
• Background: a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.
• Synonyms: NSP2; SH2D3B
• Note: BCAR3 Antibody detects endogenous levels of BCAR3

Reference Data

• Protein Families: Druggable Genome