alpha smooth muscle Actin (ACTA2) Rabbit Polyclonal Antibody

CAT#: TA347823

Rabbit Polyclonal Anti-alpha-SMA antibody

Product Images

Western blot analysis on JK using alpha-SMA antibody, the lane on the left is blocked with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-alpha-SMA antibody: Synthetic peptide corresponding to N terminal residues of Human alpha smooth muscle Actin.
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 45 KD
• Gene Name: actin, alpha 2, smooth muscle, aorta
• Database Link:
  NP_001604
  Entrez Gene 11475 MouseEntrez Gene 81633 RatEntrez Gene 59 Human
  UniProt ID P62736
• Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
• Synonyms: AAT6; ACTSA; MYMY5
• Note: alpha-SMA antibody detects endogenous levels of alpha-SMA.

Reference Data

• Protein Pathways: Vascular smooth muscle contraction