ERAB (HSD17B10) Rabbit Polyclonal Antibody

CAT#: TA347827

Rabbit Polyclonal Anti-ERAB Antibody

Product Images

Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-ERAB Antibody: Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27kd
• Gene Name: hydroxysteroid (17-beta) dehydrogenase 10
• Database Link:
  NP_004484
  Entrez Gene 15108 MouseEntrez Gene 63864 RatEntrez Gene 3028 Human
  UniProt ID Q99714
• Background: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
• Synonyms: 17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD
• Note: The antibody detects endogenous level of total ERAB protein.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Metabolic pathways, Valine, leucine and isoleucine degradation