LIN28B Rabbit Polyclonal Antibody

CAT#: TA347832

Rabbit Polyclonal Anti-LIN28B Antibody

Product Images

Western blot analysis of extracts from Hela and 293 cells using LIN28B Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-LIN28B Antibody: Peptide sequence around aa.242~246( P-S-V-Q-K) derived from Human LIN28B
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 21 32kd
• Gene Name: lin-28 homolog B
• Database Link:
  NP_001004317
  Entrez Gene 389421 Human
  UniProt ID Q6ZN17
• Background: Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7.
• Synonyms: CSDD2
• Note: The antibody detects endogenous levels of total LIN28B protein.