RING1 Rabbit Polyclonal Antibody

CAT#: TA347834

Rabbit Polyclonal Anti-Ring1A Antibody

Product Images

Western blot analysis of extract from Hela cells using Ring1A Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Ring1A Antibody: Peptide sequence around aa.35~39( I-A-V-S-P) derived from Human Ring1A.
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58kd
• Gene Name: ring finger protein 1
• Database Link:
  NP_002922
  Entrez Gene 19763 MouseEntrez Gene 309626 RatEntrez Gene 6015 Human
  UniProt ID Q06587
• Background: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.
• Synonyms: RING1A; RNF1
• Note: The antibody detects endogenous level of total Ring1A protein.

Reference Data

• Protein Families: Druggable Genome, Transcription Factors