Myelin Basic Protein (MBP) Rabbit Polyclonal Antibody

CAT#: TA347839

Rabbit Polyclonal Anti-MBP(myelin basic protein) Antibody

Product Images

Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using MBP Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-MBP(myelin basic protein) Antibody: Peptide sequence around aa.291~295(G-G-R-D-S
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 14~33kd
• Gene Name: myelin basic protein
• Database Link:
  NP_001020252
  Entrez Gene 17196 MouseEntrez Gene 24547 RatEntrez Gene 4155 Human
  UniProt ID P02686
• Background: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
• Synonyms: MGC99675
• Note: The antibody detects endogenous level of total MBP(myelin basic protein) protein.