Hamartin (TSC1) Rabbit Polyclonal Antibody

CAT#: TA347864

Rabbit Polyclonal Anti-TSC1 Antibody

Product Images

Western blot analysis of TSC1 expression in HeLa cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TSC1 Antibody: A synthesized peptide
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 150-170 KD
• Gene Name: tuberous sclerosis 1
• Database Link:
  NP_000359
  Entrez Gene 60445 RatEntrez Gene 64930 MouseEntrez Gene 7248 Human
  UniProt ID Q92574
• Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
• Synonyms: LAM; TSC
• Note: TSC1 Antibody detects endogenous levels of total TSC1

Reference Data

• Protein Pathways: Insulin signaling pathway, mTOR signaling pathway