Dynamin 1 (DNM1) Rabbit Polyclonal Antibody

CAT#: TA348433

Rabbit Polyclonal Anti-Phospho-DYN1(Ser778) Antibody

Product Images

Western blot analysis on mouse brain cell lysate using Phospho-DYN1 (Ser778) Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Phospho-DYN1(Ser778) Antibody: A synthesized peptide derived from human DYN1 around the phosphorylation site of Sersine 778
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 100 kDa
• Gene Name: dynamin 1
• Database Link:
  NP_004399
  Entrez Gene 13429 MouseEntrez Gene 140694 RatEntrez Gene 1759 Human
  UniProt ID Q05193
• Background: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. This gene is located on chromosome 9. More than sixty highly conserved copies of the 3' region of this gene are found on other chromosomes, particularly chromosomes Y and 15. These copies are referred to as DNM1DN duplicons. Multiple splice variants exist for this gene but only two alternatively spliced transcripts encoding distinct isoforms have been described completely.
• Synonyms: DNM; EIEE31
• Note: Phospho-DYN1(Ser778) Antibody detects endogenous levels of DYN1 only when phosphorylated at Sersine 778

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis, Fc gamma R-mediated phagocytosis