GAB2 Rabbit Polyclonal Antibody

CAT#: TA348438

Rabbit Polyclonal Anti-Phospho-Gab2(Tyr452) Antibody

Product Images

Western blot analysis on HT29 cell lysate using Phospho-Gab2 (Tyr452) Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Phospho-Gab2(Tyr452) Antibody: A synthesized peptide derived from human Gab2 around the phosphorylation site of Tyrosine 452
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 75 kDa
• Gene Name: GRB2 associated binding protein 2
• Database Link:
  NP_536739
  Entrez Gene 14389 MouseEntrez Gene 84477 RatEntrez Gene 9846 Human
  UniProt ID Q9UQC2
• Background: This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
• Synonyms: KIAA0571
• Note: Phospho-Gab2(Tyr452) Antibody detects endogenous levels of Gab2 only when phosphorylated at Tyrosine 452

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis