p95 NBS1 (NBN) Rabbit Polyclonal Antibody

CAT#: TA348447

Rabbit Polyclonal Anti-Phospho-Nibrin(Ser278) Antibody

Product Images

Western blot analysis on HuvEc cell lysate using Phospho-Nibrin (Ser278) Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Phospho-Nibrin(Ser278) Antibody: A synthesized peptide derived from human Nibrin around the phosphorylation site of Sersine 278
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 85 kDa
• Gene Name: nibrin
• Database Link:
  NP_002476
  Entrez Gene 4683 Human
  UniProt ID O60934
• Background: NBS1 is a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome.
• Synonyms: AT-V1; AT-V2; ATV; NBS; NBS1; P95
• Note: Phospho-Nibrin(Ser278) Antibody detects endogenous levels of Nibrin only when phosphorylated at Sersine 278

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Homologous recombination