Caspase 1 (CASP1) Rabbit Polyclonal Antibody

CAT#: TA348921

Rabbit Polyclonal Anti-Caspase 1 (Phospho-Ser376) Antibody

Product Images

Western blot analysis of Caspase 1 (Phospho-Ser376) expression in 293 cells

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Caspase 1 (Phospho-Ser376) Antibody: A synthesized peptide derived from human Caspase 1 (Phospho-Ser376)
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27 kDa
• Gene Name: caspase 1
• Database Link:
  NP_150634
  Entrez Gene 12362 MouseEntrez Gene 834 Human
  UniProt ID P29466
• Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
• Synonyms: ICE; IL1BC; P45
• Note: Caspase 1 (Phospho-Ser376) Antibody detects endogenous levels of total Caspase 1 (Phospho-Ser376)

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway