PON2 Goat Polyclonal Antibody

CAT#: TA348946

Goat Polyclonal Anti-PON2 Antibody

Product Images

TA348946 (2 ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 2-4 ug/ml
• Reactivities: Human (Expected from sequence similarity: Mouse, Rat, Dog, Pig, Cow)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for Anti-PON2 Antibody: Peptide with sequence C-ERLLALRNRLKAS, from the internal region of the protein sequence according to NP_000296.2; NP_001018171.1.
• Formulation: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: paraoxonase 2
• Database Link:
  NP_000296
  Entrez Gene 296851 RatEntrez Gene 330260 MouseEntrez Gene 403855 DogEntrez Gene 5445 Human
  UniProt ID Q15165
• Background: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
• Synonyms: A-esterase 2; aromatic esterase 2; arylesterase 2; paraoxonase 2; paraoxonase nirs; serum aryldialkylphosphatase 2; serum paraoxonase
• Note: This antibody is expected to recognize isoforms 1 and 2 (NP_000296.2; NP_001018171.1).

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways