CLPP Goat Polyclonal Antibody

CAT#: TA348955

Goat Polyclonal Anti-AIFM1 Antibody

Product Images

TA348955 (0.01 ug/ml) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.01-0.03 ug/ml
• Reactivities: Human (Expected from sequence similarity: Mouse, Rat, Dog, Pig, Cow)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for Anti-AIFM1 Antibody: Peptide with sequence C-NEVAKLFNIHED, from the C Terminus of the protein sequence according to NP_004199.1; NP_665811.1; NP_665812.1; NP_001124318.1.
• Formulation: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
• Database Link:
  NP_006003
  Entrez Gene 301117 RatEntrez Gene 611738 DogEntrez Gene 8192 Human
  UniProt ID Q16740
• Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]
• Synonyms: DFNB81; PRLTS3
• Note: This antibody is expected to recognize isoform 1 (NP_004199.1), isoform 2 (NP_665811.1), isoform 3 (NP_665812.1) and isoform 4 (NP_001124318.1).

Reference Data

• Protein Families: Druggable Genome, Protease