ROR1 Goat Polyclonal Antibody

CAT#: TA348984

Goat Polyclonal Anti-ROR1 Antibody

Product Images

TA348984 (5 ug/ml) staining of paraffin embedded Human Breast cancer. Heated antigen retrieval with citrate buffer pH 6, DAB-staining.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 3-6 ug/ml
• Reactivities: Human (Expected from sequence similarity: Mouse, Rat)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for Anti-ROR1 Antibody: Peptide with sequence C-GNKSQKPYKIDSKQA, from the C-Terminus (near) of the protein sequence according to NP_005003.2.
• Formulation: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: receptor tyrosine kinase-like orphan receptor 1
• Database Link:
  NP_005003
  Entrez Gene 26563 MouseEntrez Gene 362550 RatEntrez Gene 4919 Human
  UniProt ID Q01973
• Background: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
• Synonyms: dJ537F10.1; NTRKR1
• Note: This antibody is expected to recognize isoform 1 (NP_005003.2) only.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane