Vinculin (VCL) Mouse Monoclonal Antibody [Clone ID: 7E10]
Frequently bought together (3)
Recombinant protein of human vinculin (VCL), transcript variant 2
USD 439.00
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Specifications
Product Data | |
Clone Name | 7E10 |
Applications | WB |
Recommended Dilution | WB: 0.5 - 1 ug/mL |
Reactivities | Chicken, Human, Mouse, Rabbit, Rat |
Host | Mouse |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Vinculin antibody is purified via Protein A prification. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | Predicted: 117 kDa; Observed: 120 kDa |
Gene Name | vinculin |
Database Link | |
Background | Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5). |
Synonyms | CMD1W; CMH15; HEL114; MV; MVCL |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
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