APOBEC3B Rabbit Polyclonal Antibody

CAT#: TA349029

Rabbit Polyclonal Anti-APOBEC3B Antibody

Product Images

Western blot analysis of APOBEC3B in rat small intestine tissue lysate with APOBEC3B antibody at 1 ug/mL.

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  Immunohistochemistry of APOBEC3B in human small intestine tissue with APOBEC3B antibody at 5 ug/mL.

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  Immunofluorescence of APOBEC3B in human small intestine tissue with APOBEC3B antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APOBEC3B antibody was raised against a 14 amino acid peptide near the amino terminus of human APOBEC3B.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: APOBEC3B antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 42 kDa; Observed: 48 kDa
• Gene Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3B
• Database Link:
  NP_001257340
  Entrez Gene 315137 RatEntrez Gene 9582 Human
  UniProt ID Q9UH17
• Background: The Apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytosine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates (1). Similar to TRIM5? which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection (2,3). APOBEC3B has also been shown to be upregulated in several cancers; it is thought that APOBEC3B-catalyzed genomic uracil lesions are responsible for a large proportion of mutations in multiple distinct cancers (4).
• Synonyms: A3B; APOBEC1L; ARCD3; ARP4; bK150C2.2; DJ742C19.2; PHRBNL