SOX18 Rabbit Polyclonal Antibody

CAT#: TA349032

Rabbit Polyclonal Anti-TET2 Antibody

Product Images

Western blot analysis of TET2 in 3T3 cell lysate with TET2 antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TET2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TET2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 220 kDa; Observed: 220 kDa
• Gene Name: SRY-box 18
• Database Link:
  NP_060889
  Entrez Gene 20672 MouseEntrez Gene 54345 Human
  UniProt ID P35713
• Background: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2). Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
• Synonyms: HLTRS; HLTS

Reference Data

• Protein Families: Transcription Factors