SOX17 Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human SRY (sex determining region Y)-box 17 (SOX17)
USD 823.00
Transient overexpression lysate of SRY (sex determining region Y)-box 17 (SOX17)
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Other products for "SOX17"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | SMURF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human SMURF2. The immunogen is located within amino acids 140 - 190 of SMURF2. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | SMURF2 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | Predicted: 82 kDa; Observed: 85 kDa |
Gene Name | SRY-box 17 |
Database Link | |
Background | SMURF2 (SMAD ubiquitin regulatory factor 2) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF2 is widely expressed and was initially identified as an inhibitor of TGF-beta/BMP signaling by targeting R-Smads and TGF type I receptor for ubiquitination and degradation (3). Studies have shown that SMURF2 functions as a tumor suppressor by maintaining genomic stability through targeting RNF20 (3). SMURF2 associates constitutively with SMAD7 (4). |
Synonyms | VUR3 |
Reference Data | |
Protein Families | Transcription Factors |
Protein Pathways | Wnt signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.