SMURF1 Rabbit Polyclonal Antibody

CAT#: TA349048

Rabbit Polyclonal Anti-MIB1 Antibody


USD 484.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen MIB1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human MIB1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification MIB1 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 89, 102, 111 kDa; Observed: 103 kDa
Gene Name SMAD specific E3 ubiquitin protein ligase 1
Background The E3 ubiquitin-protein ligase MIB1, also known as Mindbomb homolog 1, contains multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase (1). MIB1 interacts with and regulates the cellular expression of the death-associated protein kinase 1 (DAPK1) protein by promoting its ubiquitination and degradation (1). It also positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis (2).
Synonyms KIAA1625
Reference Data
Protein Families Druggable Genome
Protein Pathways Endocytosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.