Calcium Sensing Receptor (CASR) Rabbit Polyclonal Antibody

CAT#: TA349050

Rabbit Polyclonal Anti-CASR Antibody

Product Images

Western blot analysis of CASR in EL4 cell lysate with CASR antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

• 

  Immunohistochemistry of CASR in human kidney tissue with CASR antibody at 5 ug/mL.

• 

  Immunofluorescence of CASR in human kidney tissue with CASR antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CASR antibody was raised against a 15 amino acid peptide near the amino terminus of human CASR.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CASR antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 101, 120 kDa; Observed: 115, 125 kDa
• Gene Name: calcium sensing receptor
• Database Link:
  NP_000379
  Entrez Gene 12374 MouseEntrez Gene 24247 RatEntrez Gene 846 Human
  UniProt ID P41180
• Background: The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1,2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).
• Synonyms: CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; HYPOC1; NSHPT; PCAR1

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane