FKBP12 (FKBP1A) Rabbit Polyclonal Antibody

CAT#: TA349052

Rabbit Polyclonal Anti-FKBP12 Antibody

Product Images

Western blot analysis of FKBP12 in A431 cell lysate with FKBP12 antibody at 1 ug/mL.

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  Immunocytochemistry of FKBP12 in A431 cells with FKBP12 antibody at 5 ug/mL.

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  Immunofluorescence of FKBP12 in A431 cells with FKBP12 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FKBP12 antibody was raised against an 18 amino acid peptide near the center of human FKBP12.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: FKBP12 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 12 kDa; Observed: 12 kDa
• Gene Name: FK506 binding protein 1A
• Database Link:
  NP_000792
  Entrez Gene 14225 MouseEntrez Gene 25639 RatEntrez Gene 2280 Human
  UniProt ID P62942
• Background: FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function (1). FKBP12, also called FKBP1, was originally identified as a target of FK506 and rapamycin activity and catalyzes the transition between cis and transproline residues critical for proper folding of proteins (2). FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein that is an important regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release (3-5).
• Synonyms: FKBP-1A; FKBP-12; FKBP1; FKBP12; PKC12; PKCI2; PPIASE

Reference Data

• Protein Families: Druggable Genome