Mitofusin 2 (MFN2) Rabbit Polyclonal Antibody

CAT#: TA349064

Rabbit Polyclonal Anti-MFN2 Antibody

Product Images

Western blot analysis of MFN2 in human brain tissue lysate with MFN2 antibody at 1ug/ml.

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  Immunohistochemistry of MFN2 in mouse brain tissue with MFN2 antibody at 5ug/ml.

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  Immunohistochemistry of MFN2 in rat brain tissue with MFN2 antibody at 5ug/ml.

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  Immunofluorescence of MFN2 in rat brain tissue with MFN2 antibody at 20ug/ml.

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  Immunofluorescence of MFN2 in mouse brain tissue with MFN2 antibody at 20ug/ml.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2. The immunogen is located within amino acids 250 - 300 of MFN2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: MFN2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 83 kDa; Observed: 90 kDa
• Gene Name: mitofusin 2
• Database Link:
  NP_055689
  Entrez Gene 64476 RatEntrez Gene 170731 MouseEntrez Gene 9927 Human
  UniProt ID O95140
• Background: Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).
• Synonyms: ARF-GEP100; ARFGEP100; BRAG2; GEP100

Reference Data

• Protein Families: Transmembrane