Parkin (PARK2) Rabbit Polyclonal Antibody

CAT#: TA349067

Rabbit Polyclonal Anti-PDCL Antibody

Product Images

Western blot analysis of PDCL in K562 cell lysate with PDCL antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PDCL antibody was raised against a 16 amino acid peptide near the amino terminus of human PDCL.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PDCL antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 33 kDa; Observed: 35 kDa
• Gene Name: parkin RBR E3 ubiquitin protein ligase
• Database Link:
  NP_054642
  Entrez Gene 50873 MouseEntrez Gene 56816 RatEntrez Gene 5071 Human
  UniProt ID O60260
• Background: Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3). It is an ethanol-responsive modulator of heterotrimeric G proteins (4).
• Synonyms: AR-JP; LPRS2; PDJ; PRKN

Reference Data

• Protein Pathways: Parkinson's disease, Ubiquitin mediated proteolysis