P4HB Rabbit Polyclonal Antibody

CAT#: TA349075

Rabbit Polyclonal Anti-PARK2 Antibody

Product Images

Western blot analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 ug/mL.

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  Immunohistochemistry of PARK2 in human brain tissue with PARK2 antibody at 5 ug/mL.

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  Immunofluorescence of PARK2 in human brain tissue with PARK2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PARK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human PARK2
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PARK2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 51 kDa; Observed: 55 kDa
• Gene Name: prolyl 4-hydroxylase subunit beta
• Database Link:
  NP_000909
  Entrez Gene 5034 Human
  UniProt ID P07237
• Background: Parkinson’s disease (PD) is a neurodegenerative disease whose symptoms include tremors, rigidity, bradykinesia, and postural instability (1). Mutations in the PARK2 gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease (2). The PARK2 protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation (3). Recent studies have suggested that PARK2 expression reduces the mitochondrial accumulation of the apoptosis protein Bax under basal conditions and directly ubiquitinates Bax, thereby promoting cell survival (4).
• Synonyms: DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB

Reference Data

• Protein Families: Druggable Genome