RSPO3 Rabbit Polyclonal Antibody

CAT#: TA349076

Rabbit Polyclonal Anti-ATG4C Antibody

Product Images

Western blot analysis of ATG4C in A549 cell lysate with ATG4C antibody at 1 ug/mL.

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  Immunohistochemistry of ATG4C in human lung tissue with ATG4C antibody at 5 ug/mL.

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  Immunofluorescence of ATG4C in human lung tissue with ATG4C antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATG4C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4C
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ATG4C antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 50 kDa; Observed: 57 kDa
• Gene Name: R-spondin 3
• Database Link:
  NP_116173
  Entrez Gene 72780 MouseEntrez Gene 498997 RatEntrez Gene 84870 Human
  UniProt ID Q9BXY4
• Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b; overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4).
• Synonyms: CRISTIN1; PWTSR; THSD2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein