NADPH oxidase 4 (NOX4) Rabbit Polyclonal Antibody

CAT#: TA349082

Rabbit Polyclonal Anti-NOX3 Antibody


USD 484.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen NOX3 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX3.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification NOX3 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 62 kDa; Observed: 72 kDa
Gene Name NADPH oxidase 4
Background The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3). It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4).
Synonyms KOX; KOX-1; RENOX
Reference Data
Protein Families Druggable Genome, Transmembrane

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