BAMBI Rabbit Polyclonal Antibody

CAT#: TA349085

Rabbit Polyclonal Anti-BAMBI Antibody

Product Images

Western blot analysis of BAMBI in mouse lung tissue lysate with BAMBI antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of BAMBI in human lung tissue with BAMBI antibody at 5 ug/mL.

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  Immunofluorescence of BAMBI in human lung tissue with BAMBI antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BAMBI antibody was raised against a 17 amino acid peptide near the center of human BAMBI.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: BAMBI antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 29 kDa; Observed: 26 kDa
• Gene Name: BMP and activin membrane-bound inhibitor
• Database Link:
  NP_036474
  Entrez Gene 68010 MouseEntrez Gene 83837 RatEntrez Gene 25805 Human
  UniProt ID Q13145
• Background: BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1). BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3). BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4). BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5).
• Synonyms: NMA

Reference Data

• Protein Families: Transmembrane