CD55 Rabbit Polyclonal Antibody

CAT#: TA349088

Rabbit Polyclonal Anti-DAF Antibody

Product Images

Western blot analysis of DAF in A549 cell lysate with DAF antibody at 1ug/ml.

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  Western blot analysis of DAF1 expression in HeLa cell lysate with DAF1 antibody at (A) 1 and (B) 2ug/ml.

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  Immunohistochemistry of DAF in human lung tissue with DAF antibody at 5ug/ml.

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  Immunofluorescence of DAF in human lung tissue with DAF antibody at 20ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DAF antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DAF. The immunogen is located within amino acids 360 - 410 of DAF.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DAF antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 48 kDa; Observed: 49 kDa
• Gene Name: CD55 molecule (Cromer blood group)
• Database Link:
  NP_000565
  Entrez Gene 1604 Human
  UniProt ID P08174
• Background: The decay-accelerating factor (DAF), also known as CD55, is an integral membrane glycoprotein that is involved in the regulation of the complement cascade (1). DAF limits excessive complement activation by accelerating their decay following DAF binding, thereby disrupting the cascade and preventing damage to host cells (2). Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM) (3).
• Synonyms: CR; CROM; DAF; TC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Hematopoietic cell lineage, Viral myocarditis