MIB1 Rabbit Polyclonal Antibody

CAT#: TA349101

Rabbit Polyclonal Anti-NLGN2 Antibody

Product Images

Western blot analysis of NLGN2 in rat brain tissue lysate with NLGN2 antibody at (A) 1 and (B) 2 ug/mL.

• 

  Immunohistochemistry of NLGN2 in mouse brain tissue with NLGN2 antibody at 5 ug/mL.

• 

  Immunofluorescence of NLGN2 in mouse brain tissue with NLGN2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NLGN2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human NLGN2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NLGN2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 92, 99 kDa; Observed: 80, 97 kDa
• Gene Name: mindbomb E3 ubiquitin protein ligase 1
• Database Link:
  NP_065825
  Entrez Gene 225164 MouseEntrez Gene 307594 RatEntrez Gene 57534 Human
  UniProt ID Q86YT6
• Background: Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2). Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2). NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4). NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5).
• Synonyms: DIP-1; DIP1; LVNC7; MIB; ZZANK2; ZZZ6

Reference Data

• Protein Families: Druggable Genome