MYO7B Rabbit Polyclonal Antibody

CAT#: TA349105

Rabbit Polyclonal Anti-Nephrin Antibody

Product Images

Western blot analysis of Nephrin in human kidney tissue lysate with Nephrin antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Nephrin antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Nephrin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Nephrin antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 125, 137 kDa; Observed: 125 kDa
• Gene Name: myosin VIIB
• Database Link:
  NP_001073996
  Entrez Gene 4648 Human
  UniProt ID Q6PIF6
• Background: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth (1). Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3).
• Synonyms: DKFZp686A08248