IQSEC1 Rabbit Polyclonal Antibody

CAT#: TA349112

Rabbit Polyclonal Anti-IQSEC1 Antibody

Product Images

Western blot analysis of IQSEC1 in A20 cell lysate with IQSEC1 antibody at 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IQSEC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human IQSEC1
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IQSEC1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 106 kDa; Observed: 103 kDa
• Gene Name: IQ motif and Sec7 domain 1
• Database Link:
  NP_055684
  Entrez Gene 232227 MouseEntrez Gene 686590 RatEntrez Gene 9922 Human
  UniProt ID Q6DN90
• Background: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1). As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3). IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4).
• Synonyms: NICE-4; NICE4

Reference Data

• Protein Pathways: Endocytosis