IQSEC2 Rabbit Polyclonal Antibody

CAT#: TA349113

Rabbit Polyclonal Anti-IQSEC2 Antibody

Product Images

Western blot analysis of IQSEC2 in SK-N-SH cell lysate with IQSEC2 antibody at 1 ug/mL.

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  Immunohistochemistry of IQSEC2 in mouse brain tissue with IQSEC2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IQSEC2 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 104, 133, 141, 164 kDa; Observed: 140 kD
• Gene Name: IQ motif and Sec7 domain 2
• Database Link:
  NP_001104595
  Entrez Gene 245666 MouseEntrez Gene 685244 RatEntrez Gene 23096 Human
  UniProt ID Q5JU85
• Background: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).
• Synonyms: BRAG1; MRX1

Reference Data

• Protein Pathways: Endocytosis