GLIS2 Rabbit Polyclonal Antibody

CAT#: TA349114

Rabbit Polyclonal Anti-PTPN5 Antibody

Product Images

Western blot analysis of PTPN5 in Jurkat cell lysate with PTPN5 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 ug/mL.

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  Immunofluorescence of PTPN5 in mouse brain tissue with PTPN5 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PTPN5 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 62 kDa; Observed: 60 kDa
• Gene Name: GLIS family zinc finger 2
• Database Link:
  NP_115964
  Entrez Gene 83396 MouseEntrez Gene 84662 Human
  UniProt ID Q9BZE0
• Background: The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).
• Synonyms: NKL; NPHP7

Reference Data

• Protein Families: ES Cell Differentiation/IPS